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    <p>I'm going to assume that by "business application" you mean a web application hosted in an intranet environment as opposed to some sort of SaaS application on the internet.</p> <p>While you're in the process of architecting your application you need to consider the existing infrastructure and infrastructure support people of your employer/customer. Also, if the company is large enough to have things such as "approved software/hardware lists," you should be aware of those. Keep in mind that some elements of the list may be downright retarded. Don't let past mistakes dictate the architecture of your app, but in cases where they are reasonably sensible I would pick my battles and stick with your enterprise standard. This can be a real pain when you pick a development stack that really works best on Unix/Linux, and then someone tries to force onto a Windows server admined by someone who's never touched anything but ASP.NET applications.</p> <p>Unless there is a particular PHP module that you intend to use that has no Python equivalent, I would drop PHP and use Django. If there is a compelling reason to use PHP, then I'd drop Python. I'm having difficulty imagining a scenario where you would want to use both at the same time.</p> <p>As for PG versus MySQL, either works. Look at what you customer already has deployed, and if they have a bunch of one and little of another, pick that. If they have existing Oracle infrastructure you should consider using it. If they are an SQL Server shop...reconsider your stack and remember to pick your battles.</p>
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