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    <p>It appears that C extension modules included with the wxPython 2.7 dmg <a href="http://www.wxpython.org/download.php" rel="noreferrer">here</a> are 32-bit only.</p> <pre><code>$ cd /usr/local/lib/wxPython-unicode-2.8.11.0/lib/python2.7/site-packages/wx-2.8-mac-unicode/wx $ file *.so _animate.so: Mach-O universal binary with 2 architectures _animate.so (for architecture ppc): Mach-O bundle ppc _animate.so (for architecture i386): Mach-O bundle i386 _aui.so: Mach-O universal binary with 2 architectures _aui.so (for architecture ppc): Mach-O bundle ppc _aui.so (for architecture i386): Mach-O bundle i386 ... </code></pre> <p>Unfortunately, <code>platform.architecture()</code> does not give an accurate indication of which arch an OS X multiple architecture Python is running in. For example, using the 3-arch python.org installer for Python 2.7, <code>platform.architecture()</code> always reports 64-bit even when running in 32-bit mode:</p> <pre><code>$ cd /Library/Frameworks/Python.framework/Versions/2.7 $ file python2.7 python2.7: Mach-O universal binary with 3 architectures python2.7 (for architecture i386): Mach-O executable i386 python2.7 (for architecture ppc7400): Mach-O executable ppc python2.7 (for architecture x86_64): Mach-O 64-bit executable x86_64 $ arch -x86_64 ./python2.7 -c 'import platform, sys; print "{0}, {1:x}".format(platform.architecture()[0], sys.maxint)' 64bit, 7fffffffffffffff $ arch -i386 ./python2.7 -c 'import platform, sys; print "{0}, {1:x}".format(platform.architecture()[0], sys.maxint)' 64bit, 7fffffff $ arch -ppc ./python2.7 -c 'import platform, sys; print "{0}, {1:x}".format(platform.architecture()[0], sys.maxint)' 64bit, 7fffffff </code></pre> <p>The reliable way is to examine <code>sys.maxint</code> for Python 2 or <code>sys.maxsize</code> for Python 3.</p> <p>You don't indicate in your question how you invoke Python. Is it via a shebang line in a script file? If so, you may not be running the Python you think you are. Also, you don't indicate which Python 2.7 you have installed. For instance, there are currently two installers for Python 2.7 from python.org: one supports both 32- and 64-bit execution, the other is 32-bit only. Try the following:</p> <pre><code>$ file $(python2.7 -c 'import sys;print(sys.executable)') /Library/Frameworks/Python.framework/Versions/2.7/Resources/Python.app/Contents/MacOS/Python: Mach-O universal binary with 3 architectures /Library/Frameworks/Python.framework/Versions/2.7/Resources/Python.app/Contents/MacOS/Python (for architecture i386): Mach-O executable i386 /Library/Frameworks/Python.framework/Versions/2.7/Resources/Python.app/Contents/MacOS/Python (for architecture ppc7400): Mach-O executable ppc /Library/Frameworks/Python.framework/Versions/2.7/Resources/Python.app/Contents/MacOS/Python (for architecture x86_64): Mach-O 64-bit executable x86_64 </code></pre> <p>So: if you have a multi-arch version of Python, you'll need to force it to run in 32-bit mode to make use of the pre-compiled wxPython.</p>
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    1. COI am running the python script from a regular terminal window, i.e., '$ python script.py'. The import is done in the regular way, right at the beginning of the script. Printing sys.maxint gives 9223372036854775807 so I guess I am running in 64 bit mode. This is what I get when I try the last bit: ../Python: Mach-O universal binary with 3 architectures ../Python (for architecture i386): Mach-O executable i386 ../Python (for architecture ppc7400)Mach-O executable ppc ../Python (for architecture x86_64):Mach-O 64-bit executable x86_64
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    2. COI just checked the other mac where wxPython worked fine, sys.maxint shows that it is running 32 bit. How can I force python to run 32 bit mode?
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    3. COYou should be able to use `arch -i386 python2.7 script.py` to run in 32-bit mode. If that proves to be troublesome and you don't otherwise need 64-bit features, you could download and install the other python.org 2.7 installer (the one marked 10.3 and above). That will overwrite your existing python2.7 installation with a 32-bit only one. You may need to re-install the wxPython afterwards.
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