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    <p>I think it could be a challenge to find reference materials for that particular combination. Many .NET shops stick to SQL Server, and fewer use MySQL (at least at scale).</p> <p>In general it would be appropriate to:</p> <ul> <li>Follow general <a href="http://msdn.microsoft.com/en-us/library/ms998530.aspx" rel="nofollow noreferrer">.NET practices for scalability</a>. Weed out what is not appropriate for you.</li> <li>Learn about database performance and implications of various design strategies such as denormalisation (when and why).</li> <li>Consider out-of-process caching like <a href="http://en.wikipedia.org/wiki/Memcached" rel="nofollow noreferrer">memcached</a>.</li> <li>Review books on <a href="http://oreilly.com/catalog/9780596101718/" rel="nofollow noreferrer">MySQL performance</a>. Most of these are focused on UNIX platforms. Windows users may have problems applying some of these practices.</li> <li>Read up on how other people are scaling their sites (<a href="http://oreilly.com/catalog/9780596102357/" rel="nofollow noreferrer">Building Scalable Sites</a> and <a href="http://oreilly.com/catalog/9780596518578/" rel="nofollow noreferrer">The Art of Capacity Planning</a>)</li> <li>Consider how you might optimise your web design to be more scalable. Are you using AJAX? Work out what the impact of excessive polling may be etc.</li> <li>Learn how to measure the performance of your application and database (starting points <a href="http://www.google.com/search?hl=en&amp;q=measuring+asp.net+performance" rel="nofollow noreferrer">ASP.NET</a> and <a href="http://www.google.com/search?hl=en&amp;q=measuring+mysql+performance&amp;btnG=Search" rel="nofollow noreferrer">MySQL</a>).</li> <li>Develop a plan for scaling your architecture (1 server to 2 servers, to multiple servers etc) so that you have some frame of reference for making decisions about building things in your system.</li> </ul>
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