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    <p>You have to implement <code>INotifyPropertyChanged</code>, only then the changes will be updated in UI.</p> <p>Here are the modifications that I've done to your code.</p> <pre><code>using System; using System.Collections.Generic; using System.Linq; using System.Text; using System.Windows; using System.Windows.Controls; using System.Windows.Data; using System.Windows.Documents; using System.Windows.Input; using System.Windows.Media; using System.Windows.Media.Imaging; using System.Windows.Navigation; using System.Windows.Shapes; using System.ComponentModel; using System.Collections.ObjectModel; namespace WpfApplication1 { /// &lt;summary&gt; /// Interaction logic for MainWindow.xaml /// &lt;/summary&gt; public partial class MainWindow : Window, INotifyPropertyChanged { private Molecule _CurrentMolecule; public Molecule CurrentMolecule { get { return _CurrentMolecule; } set { _CurrentMolecule = value; OnPropertyChanged("CurrentMolecule"); Formulas = new ObservableCollection&lt;string&gt;(CurrentMolecule.FormulasList.ToList()); } } private ObservableCollection&lt;string&gt; _Formulas; public ObservableCollection&lt;string&gt; Formulas { get { return _Formulas; } set { _Formulas = value; OnPropertyChanged("Formulas"); } } public MainWindow() { InitializeComponent(); CurrentMolecule = new Molecule(); DataContext = this; } public event PropertyChangedEventHandler PropertyChanged; public void OnPropertyChanged(string propertyName) { if (PropertyChanged != null) { PropertyChanged(this, new PropertyChangedEventArgs(propertyName)); } } } } </code></pre> <p>Edit: A better approach is to create a ViewModel and then bind it to the DataContext of the <code>Window</code>. </p> <p>Define a new class called <code>ViewModel</code> as below. Note you might want to change the namespace</p> <pre><code>using System; using System.Collections.Generic; using System.Linq; using System.Text; using System.ComponentModel; using System.Collections.ObjectModel; namespace WpfApplication1 { public class ViewModel : INotifyPropertyChanged { #region Properties private Molecule _CurrentMolecule; public Molecule CurrentMolecule { get { return _CurrentMolecule; } set { _CurrentMolecule = value; OnPropertyChanged("CurrentMolecule"); Formulas = new ObservableCollection&lt;string&gt;(CurrentMolecule.FormulasList.ToList()); } } private ObservableCollection&lt;string&gt; _Formulas; public ObservableCollection&lt;string&gt; Formulas { get { return _Formulas; } set { _Formulas = value; OnPropertyChanged("Formulas"); } } #endregion #region Constructor public ViewModel() { CurrentMolecule = new Molecule(); } #endregion #region INotifyPropertyChanged implementation public event PropertyChangedEventHandler PropertyChanged; public void OnPropertyChanged(string propertyName) { if (PropertyChanged != null) { PropertyChanged(this, new PropertyChangedEventArgs(propertyName)); } } #endregion } } </code></pre> <p>Modify the <code>MainWindow</code> code behind file as below</p> <pre><code>public MainWindow() { InitializeComponent(); DataContext = new ViewModel(); } </code></pre>
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    1. COWhile this solution may actually work, I strongly discourage the use of `INotifyPropertyChanged` in `DependencyObject`-derived classes. `INotifyPropertyChanged` is a ViewModel-concept, IMO, and should not be mashed all together with the View itself.
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      1. USFederico Berasategui
    2. COAgreed. I'll update my answer to use a simple ViewModel.
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    3. COI have edited the answer
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