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    <p>I would check the following</p> <ol> <li><p>Check the CPU usage on the server through task manager (web app and database). Is it maxed out</p></li> <li><p>Are the servers out of physical memory - again task manager</p></li> <li><p>Are the returned pages massive. This is obvious but sometimes it's not. Sheer quantity of HTML can kill a page dead. This could be hidden (ViewState, elements with display:'none') or actually on the page but you are so used to looking that you can't see</p></li> <li><p>Get fiddler onto it. Are you calling any external resources you shouldn't be. maybe there is a web service you are relying on that is suddenly inaccessible from a particular box. We had a twitter feed that was timing out that totally killed a site.</p></li> <li><p>Do profile the database. You think it can't be but are you sure. Are you sure you're sure. You might not be comparing like with like and bring back huge amounts of data on one test without realising.</p></li> <li><p>Certain processes are very sensitive to page/data length. For instance I had a regex that utterly failed and timed the page out once the page reached a certain size. The performance hardly tailed off - it stopped dead (badly written - who did that - erm me!!)</p></li> <li><p>Is the physical box just dying. Are they any other processes/sites on there that are killing it. Who are you sharing the box with? Is the hard disc on it's way out? </p></li> <li><p>Firewalls can be naughty. We have seen massive increases in performance by rebooting a physical firewall. Can you trace those packets?</p></li> </ol> <p>Any there will be more - performance debugging can be a bit of an art. But hey - we're all artists aren't we.</p>
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