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copied!<p>Sure you can. You were very close to answer in your comment to Jakob's answer - </p> <blockquote> <p>If it is possible to change file association with environment variables - it will help, but it doesn't seem possible.</p> </blockquote> <p>It is possible. All you have to do is to use <code>REG_EXPAND_SZ</code> type of registry key and environment variable in the key's value. For example putting<br> <code>%python_home%\python %1 %*</code><br> as the <code>(Default)</code> value of<br> <code>HKEY_LOCAL_MACHINE\SOFTWARE\Classes\Python.File\shell\open\command</code><br> key and setting its value to <code>REG_EXPAND_SZ</code> makes it possible to define what Python your Python files will be opened with. You decide by setting <code>python_home</code> environment variable and you can do this per command line session of course. Take a look at my answer to the question <a href="https://superuser.com/questions/266268/">where in the registry does Windows store, with which program to open certain file types?</a> </p> <p>Having said that there is now special tool for solving exactly this problem which I highly recommend. It's called <a href="https://bitbucket.org/vinay.sajip/pylauncher/overview" rel="nofollow noreferrer">pylauncher</a>. From the docs:</p> <blockquote> <p>PEP 397 compatible launcher for Python under Windows. See <a href="http://www.python.org/dev/peps/pep-0397/" rel="nofollow noreferrer">http://www.python.org/dev/peps/pep-0397/</a> for PEP, <a href="http://www.red-dove.com/screencasts/launcher/launcher.html" rel="nofollow noreferrer">http://www.red-dove.com/screencasts/launcher/launcher.html</a> for screencast</p> </blockquote> <p>You can even skip the <em>.py</em> extension if you add it to the <em>PATHEXT</em> environment variable. See the question <a href="https://superuser.com/questions/101596/">What environment variables will be used when calling an EXE from command line?</a></p>

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