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    copied!<p>There are two possibilities:</p> <ol> <li><p>Server side: subscribe for the <code>OnSelectedIndexChanged</code> event and enable AutoPostBack:</p> <pre><code>&lt;asp:CheckBoxList ID="CheckBoxList1" RepeatDirection="Horizontal" runat="server" AutoPostBack="true" OnSelectedIndexChanged="CheckBoxList1_SelectedIndexChanged"&gt; &lt;asp:ListItem Value="1"&gt;French&lt;/asp:ListItem&gt; &lt;asp:ListItem Value="2"&gt;Spanish&lt;/asp:ListItem&gt; &lt;asp:ListItem Value="3"&gt;Italian&lt;/asp:ListItem&gt; &lt;asp:ListItem Value="4"&gt;German&lt;/asp:ListItem&gt; &lt;asp:ListItem Value="5"&gt;Portuguese&lt;/asp:ListItem&gt; &lt;asp:ListItem Value="6"&gt;Chinese&lt;/asp:ListItem&gt; &lt;asp:ListItem Value="7"&gt;Japanese&lt;/asp:ListItem&gt; &lt;asp:ListItem Value="8"&gt;Russian&lt;/asp:ListItem&gt; &lt;asp:ListItem Value="Other"&gt;Other&lt;/asp:ListItem&gt; &lt;asp:ListItem Value="None"&gt;None&lt;/asp:ListItem&gt; &lt;/asp:CheckBoxList&gt; </code></pre> <p>and in the code behind:</p> <pre><code>protected void CheckBoxList1_SelectedIndexChanged(object sender, EventArgs e) { var listItems = CheckBoxList1.Items.Cast&lt;ListItem&gt;(); var isNoneSelected = listItems.Any(x =&gt; x.Value == "None" &amp;&amp; x.Selected == true); if (isNoneSelected) { listItems.Where(x =&gt; x.Value != "None").ToList().ForEach(x =&gt; x.Selected = false); } } </code></pre></li> <li><p>Client side: use javascript to detect when the user clicks on the None checkbox and uncheck the others.</p></li> </ol>
 

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