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copied!<p>As you seem to primarily target Linux, then the choice mostly depends on the programming language you want to use.</p> <p>If you code in C, then obviously go for GTK+</p> <p>If you code in C++, go for Qt, otherwise you will need <a href="http://www.gtkmm.org/" rel="noreferrer">Gtkmm</a> (a C++ wrapper over GTK+)</p> <p>If you code in Python, both GTK+ and Qt have bindings for the language: see <a href="http://www.pygtk.org/" rel="noreferrer">PyGtk</a>, <a href="http://www.riverbankcomputing.co.uk/software/pyqt/intro" rel="noreferrer">PyQt</a> and <a href="http://www.pyside.org/" rel="noreferrer">PySide</a> (the one launched by Nokia themselves).</p> <p>If you code in Java, Qt is no more a viable option imho as <a href="https://web.archive.org/web/20090221105007/http://www.qtsoftware.com/about/news/preview-of-final-qt-jambi-release-available" rel="noreferrer">Nokia discontinued Qt Jambi</a> (the Java bindings for Qt).</p> <p>Also, Qt is more top-notch regarding its scenegraph <a href="http://doc.qt.io/qt-5/qgraphicsscene.html" rel="noreferrer">QGraphicsScene</a> API, its scripting engine built over Javascript Core (the engine powering WebKit), its state machine and animations framework, and the <a href="http://blog.qt.io/blog/2009/05/13/qt-declarative-ui/" rel="noreferrer">declarative UI</a>.</p> <p>GTK+ doesn't offer that much although you can use <a href="http://www.clutter-project.org/" rel="noreferrer">Clutter</a> alongside with it.</p> <p>If you're specifically looking into DB, XML (GTK+ has a parser for a subset of XML) and threading (GTK+ has <a href="http://library.gnome.org/devel/glib/" rel="noreferrer">GLib</a>) features then Qt will offer all that in <a href="http://doc.qt.io/qt-5/qtsql-index.html" rel="noreferrer">QtSql</a>, <a href="http://doc.qt.io/qt-5/qtxml-index.html" rel="noreferrer">QtXml</a> and <a href="http://doc.qt.io/qt-5/qtconcurrent-index.html" rel="noreferrer">QtConcurrent</a>.</p> <p>All in all, I would say Qt is a sure choice. But GTK+ is very capable as well.</p> <p>I'm not sure you will get a crystal clear answer for your question, which explains why some people keep preferring Gnome over KDE or vice-versa. <strong>Choose what works best for you.</strong></p> <p>PS: I you plan to also target Symbian, then go for Qt.</p> <p>EDIT: Something that is also great with Qt is QtWebKit: it brings WebKit into your Qt application. Others are embedding WebKit into their application using for instance Awesomium or Berkelium.</p>

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